Articles related to "Tumor Suppressor"
Cancer Basics
A brief, lay description of the evolution of cancer in the body and the terminology necessary.
cells • mutations • genes • hyperplasia • dysplasia
A brief, lay description of the evolution of cancer in the body and the terminology necessary.
cells • mutations • genes • hyperplasia • dysplasia
Cancer Robustness
Robustness is the ability of cancers to adapt to changes in its environment and is a major cause of treatment failures. Viewing cancer as a robust system provides a more logical framework for the development of cancer therapies.
homeostasis • robustness • heterogeneity • feedback-control • multidrug resistance
Robustness is the ability of cancers to adapt to changes in its environment and is a major cause of treatment failures. Viewing cancer as a robust system provides a more logical framework for the development of cancer therapies.
homeostasis • robustness • heterogeneity • feedback-control • multidrug resistance
DNA Mutations Cause Cancer
People do not inherit cancer but instead inherit an increased risk of getting cancer.
cancer • familial cancer • dna mutation • cancer genetics • tumor suppressor
People do not inherit cancer but instead inherit an increased risk of getting cancer.
cancer • familial cancer • dna mutation • cancer genetics • tumor suppressor
Do Tumor-Suppressors Promote Ageing?
The body utilizes tumor-suppressor proteins to inhibit cancer formation. Although this action would seem to increase longevity, and in many cases it does, paradoxically there are situations in which it may accelerate the ageing process.
tumor-suppressors • caretaker • gatekeeper • dna • senescence
The body utilizes tumor-suppressor proteins to inhibit cancer formation. Although this action would seem to increase longevity, and in many cases it does, paradoxically there are situations in which it may accelerate the ageing process.
tumor-suppressors • caretaker • gatekeeper • dna • senescence
Nutrients for the Prevention of Colon Cancer
Although there are many causes of colon cancer, this article focuses on the role of calcium, vitamin D and folic acid in the prevention of this disease.
calcium • receptor protein • protein kinase c • apoptosis • vitamin d
Although there are many causes of colon cancer, this article focuses on the role of calcium, vitamin D and folic acid in the prevention of this disease.
calcium • receptor protein • protein kinase c • apoptosis • vitamin d
The p53 tumor suppressor gene
The p53 gene performs an essential function in its normal role as a tumor suppressor. However, it is found in a mutated form in over half of all types of cancers. A fuller understanding of p53’s activities can lead to novel approaches to cancer treatment.
p53 • tumor suppressor • oncogene • dna • p21 protein
The p53 gene performs an essential function in its normal role as a tumor suppressor. However, it is found in a mutated form in over half of all types of cancers. A fuller understanding of p53’s activities can lead to novel approaches to cancer treatment.
p53 • tumor suppressor • oncogene • dna • p21 protein
Bacterial toxins for the treatment of cancer
The use of live bacteria for the treatment of cancer has a long history, but problems with toxicity have limited its value in medicine. The field has recently been revitalized with the introduction of genetically modified bacteria, as well as the use of isolated toxins and proteins from the bacteria. These bacterial components are being studied individually and in combination with chemotherapeutic drugs in the treatment of cancer.
bacterial toxins • enterotoxins • diarrhea • tumor suppressor • p53
The use of live bacteria for the treatment of cancer has a long history, but problems with toxicity have limited its value in medicine. The field has recently been revitalized with the introduction of genetically modified bacteria, as well as the use of isolated toxins and proteins from the bacteria. These bacterial components are being studied individually and in combination with chemotherapeutic drugs in the treatment of cancer.
bacterial toxins • enterotoxins • diarrhea • tumor suppressor • p53
Cancer Gene Therapy I
Gene therapy is much in the news today. This article describes the principles behind the technology, and the criteria that must be satisfied in order for gene therapy to be successfully applied to the treatment of cancer. One of the major challenges facing the researcher is to find an effective delivery vehicle; therefore, I have presented the most common methods.
gene therapy • oncogene • dna • tumor-suppressor • cell division cycle
Gene therapy is much in the news today. This article describes the principles behind the technology, and the criteria that must be satisfied in order for gene therapy to be successfully applied to the treatment of cancer. One of the major challenges facing the researcher is to find an effective delivery vehicle; therefore, I have presented the most common methods.
gene therapy • oncogene • dna • tumor-suppressor • cell division cycle
Mouse Models in Cancer Research
The use of mouse models is an essential part of the drug development process. Much has been learned about the human cancer condition, and many drugs have been developed to treat cancer through testing with mice. However, the results of mouse studies should be treated with caution, and conclusions not drawn until human clinical trials are completed.
mouse models • genetic engineering • tumor progression • cancer research • human surrogates
The use of mouse models is an essential part of the drug development process. Much has been learned about the human cancer condition, and many drugs have been developed to treat cancer through testing with mice. However, the results of mouse studies should be treated with caution, and conclusions not drawn until human clinical trials are completed.
mouse models • genetic engineering • tumor progression • cancer research • human surrogates
Personalized therapy for Metastatic Lung Cancer
A recent study published in May 2009, reports the efficiency of personalized chemotherapy based on the genetic profile of patients affected by non-small cell lung cancer.
non-small cell lung cancer • lung cancer genetics • lung cancer gene mutation • lung cancer egfr brca1 • lung cancer oncogene tumor suppressor
A recent study published in May 2009, reports the efficiency of personalized chemotherapy based on the genetic profile of patients affected by non-small cell lung cancer.
non-small cell lung cancer • lung cancer genetics • lung cancer gene mutation • lung cancer egfr brca1 • lung cancer oncogene tumor suppressor
Breast Cancer Discrepencies
Scientists are making progress against breast cancer as diagnoses are declining and research is revealing how ethnicity may impact prevalence and risk factors.
breast cancer • racial disparities in breast cancer diagnoses • brca1 gene mutation • african american women and breast cancer • hispanic women and breast cancer
Scientists are making progress against breast cancer as diagnoses are declining and research is revealing how ethnicity may impact prevalence and risk factors.
breast cancer • racial disparities in breast cancer diagnoses • brca1 gene mutation • african american women and breast cancer • hispanic women and breast cancer
Metastasis Suppressors
Evidence is emerging that the loss of function of metastasis suppressor genes is an important factor in the development of metastasis (the spread of cancer from a primary site). Developing drugs that restore metastatic suppressor gene expression represents a new therapeutic approach to cancer treatment.
metastasis suppressor • extracellular matrix • melanoma • breast cancer • colon cancer
Evidence is emerging that the loss of function of metastasis suppressor genes is an important factor in the development of metastasis (the spread of cancer from a primary site). Developing drugs that restore metastatic suppressor gene expression represents a new therapeutic approach to cancer treatment.
metastasis suppressor • extracellular matrix • melanoma • breast cancer • colon cancer
New Developments in Gene Therapy
This article provides an update on the field of cancer gene therapy, particularly with regard to the capability of infecting cancer cells selectively.
gene therapy • bystander • infection • herpesvirus • adenovirus
This article provides an update on the field of cancer gene therapy, particularly with regard to the capability of infecting cancer cells selectively.
gene therapy • bystander • infection • herpesvirus • adenovirus
Cancer Gene Therapy II
This article concludes an introduction to cancer gene therapy. There are three broad categories for applying gene therapy to cancer treatment: (1)restoring proper gene function, (2)stimulating the body's immune system to destroy the cancer, and (3)introduce a gene that converts an inactive drug into a toxic drug.
p53 • p21 • apoptosis • antisense • mutation
This article concludes an introduction to cancer gene therapy. There are three broad categories for applying gene therapy to cancer treatment: (1)restoring proper gene function, (2)stimulating the body's immune system to destroy the cancer, and (3)introduce a gene that converts an inactive drug into a toxic drug.
p53 • p21 • apoptosis • antisense • mutation
Symptoms of Breast Cancer & Screening
Why testing is recommended before symptoms of breast cancer. Breast cancer facts about cancer risks. Breast cancer statistics about risk levels.
symptoms of breast cancer • breast cancer symptoms • cancer statistics • breast cancer statistics • breast cancer causes
Why testing is recommended before symptoms of breast cancer. Breast cancer facts about cancer risks. Breast cancer statistics about risk levels.
symptoms of breast cancer • breast cancer symptoms • cancer statistics • breast cancer statistics • breast cancer causes
Cancer Treatment in Old Age
Cancer is largely a disease of older people. As a person ages, molecular, cellular, and physiological changes in the body influence the development of cancer. These factors also influence responses to treatment. Sociological factors also influence decisions to treat the older patient.
geriatric oncology • dna defects • mitochondria • reactive oxygen species • oxidative stress
Cancer is largely a disease of older people. As a person ages, molecular, cellular, and physiological changes in the body influence the development of cancer. These factors also influence responses to treatment. Sociological factors also influence decisions to treat the older patient.
geriatric oncology • dna defects • mitochondria • reactive oxygen species • oxidative stress
Detecting Cancer with Autoantibodies
constituents. Cancer stimulates autoantibody production due to the presence of unusual proteins or excessive quantities of normal proteins. Due to the great sensitivity of the immune response, researchers are actively engaged in the discovery of autoantibodies as detection tools for cancers.
autoantibodies • antigens • antibodies • prostate specific antigen • p53 gene
constituents. Cancer stimulates autoantibody production due to the presence of unusual proteins or excessive quantities of normal proteins. Due to the great sensitivity of the immune response, researchers are actively engaged in the discovery of autoantibodies as detection tools for cancers.
autoantibodies • antigens • antibodies • prostate specific antigen • p53 gene
Ras Proteins, the Cell Cycle and Cancer
The cell cycle is a carefully choreographed series of events that lead to cell division. In cancer, a mutated gene results in the loss of normal control over this process, leading to uncontrolled cell division. this article focuses on one of the principal players in this process, the ras protein. A mutation i the ras gene leads to about 30% of all cancers.
ras • signaling • cell cycle • gdp • gtp
The cell cycle is a carefully choreographed series of events that lead to cell division. In cancer, a mutated gene results in the loss of normal control over this process, leading to uncontrolled cell division. this article focuses on one of the principal players in this process, the ras protein. A mutation i the ras gene leads to about 30% of all cancers.
ras • signaling • cell cycle • gdp • gtp
Targeting STAT Proteins for Cancer Therapy
Activation of STAT proteins by cancer cells has been shown to be an essential feature of cancer progression. A further understanding of the process can lead to novel methods of cancer therapy.
stat proteins • cytokine • tyrosine kinases • p53 • apoptosis
Activation of STAT proteins by cancer cells has been shown to be an essential feature of cancer progression. A further understanding of the process can lead to novel methods of cancer therapy.
stat proteins • cytokine • tyrosine kinases • p53 • apoptosis
The genome project and cancer research
The completion of the human genome project has provided the means for a vastly improved understanding of our genes and their location in the chromosomes. How will this aid in cancer research
genome • dna • sequence • bases • coding
The completion of the human genome project has provided the means for a vastly improved understanding of our genes and their location in the chromosomes. How will this aid in cancer research
genome • dna • sequence • bases • coding
Angiogenesis and Cancer
This article describes the process of angiogenesis and how it relates to cancer. The development of angiogenesis inhibitors that promise to limit the growth of tumors is then described.
angiogenesis • tumors • capillary • thalidomide • p53
This article describes the process of angiogenesis and how it relates to cancer. The development of angiogenesis inhibitors that promise to limit the growth of tumors is then described.
angiogenesis • tumors • capillary • thalidomide • p53
Oncolytic Viruses and Cancer Therapy
Oncolytic viruses are used to preferentially infect and kill cancer cells, while not harming normal tissues. Recent advances in virology and molecular biology have revitalized the field which now holds great promise.
oncolytic • virus • apoptosis • lysis • p53
Oncolytic viruses are used to preferentially infect and kill cancer cells, while not harming normal tissues. Recent advances in virology and molecular biology have revitalized the field which now holds great promise.
oncolytic • virus • apoptosis • lysis • p53
The Role of MicroRNAs in Cancer
MicroRNAs regulate gene expression and are playing an emerging role in the diagnosis, prognosis and therapeutic strategies for many cancers.
metastasis • cancer therapy • cancer diagnosis • cancer tumor • cancer detection
MicroRNAs regulate gene expression and are playing an emerging role in the diagnosis, prognosis and therapeutic strategies for many cancers.
metastasis • cancer therapy • cancer diagnosis • cancer tumor • cancer detection
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