Articles related to "P53"
The p53 tumor suppressor gene
The p53 gene performs an essential function in its normal role as a tumor suppressor. However, it is found in a mutated form in over half of all types of cancers. A fuller understanding of p53’s activities can lead to novel approaches to cancer treatment.
p53 • tumor suppressor • oncogene • dna • p21 protein
The p53 gene performs an essential function in its normal role as a tumor suppressor. However, it is found in a mutated form in over half of all types of cancers. A fuller understanding of p53’s activities can lead to novel approaches to cancer treatment.
p53 • tumor suppressor • oncogene • dna • p21 protein
Detecting Cancer with Autoantibodies
constituents. Cancer stimulates autoantibody production due to the presence of unusual proteins or excessive quantities of normal proteins. Due to the great sensitivity of the immune response, researchers are actively engaged in the discovery of autoantibodies as detection tools for cancers.
autoantibodies • antigens • antibodies • prostate specific antigen • p53 gene
constituents. Cancer stimulates autoantibody production due to the presence of unusual proteins or excessive quantities of normal proteins. Due to the great sensitivity of the immune response, researchers are actively engaged in the discovery of autoantibodies as detection tools for cancers.
autoantibodies • antigens • antibodies • prostate specific antigen • p53 gene
Angiogenesis and Cancer
This article describes the process of angiogenesis and how it relates to cancer. The development of angiogenesis inhibitors that promise to limit the growth of tumors is then described.
angiogenesis • tumors • capillary • thalidomide • p53
This article describes the process of angiogenesis and how it relates to cancer. The development of angiogenesis inhibitors that promise to limit the growth of tumors is then described.
angiogenesis • tumors • capillary • thalidomide • p53
New Developments in Gene Therapy
This article provides an update on the field of cancer gene therapy, particularly with regard to the capability of infecting cancer cells selectively.
gene therapy • bystander • infection • herpesvirus • adenovirus
This article provides an update on the field of cancer gene therapy, particularly with regard to the capability of infecting cancer cells selectively.
gene therapy • bystander • infection • herpesvirus • adenovirus
Oncolytic Viruses and Cancer Therapy
Oncolytic viruses are used to preferentially infect and kill cancer cells, while not harming normal tissues. Recent advances in virology and molecular biology have revitalized the field which now holds great promise.
oncolytic • virus • apoptosis • lysis • p53
Oncolytic viruses are used to preferentially infect and kill cancer cells, while not harming normal tissues. Recent advances in virology and molecular biology have revitalized the field which now holds great promise.
oncolytic • virus • apoptosis • lysis • p53
Ras Proteins, the Cell Cycle and Cancer
The cell cycle is a carefully choreographed series of events that lead to cell division. In cancer, a mutated gene results in the loss of normal control over this process, leading to uncontrolled cell division. this article focuses on one of the principal players in this process, the ras protein. A mutation i the ras gene leads to about 30% of all cancers.
ras • signaling • cell cycle • gdp • gtp
The cell cycle is a carefully choreographed series of events that lead to cell division. In cancer, a mutated gene results in the loss of normal control over this process, leading to uncontrolled cell division. this article focuses on one of the principal players in this process, the ras protein. A mutation i the ras gene leads to about 30% of all cancers.
ras • signaling • cell cycle • gdp • gtp
Resistance to Anticancer Drugs-1
The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.,The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.
chemotherapy • drug resistance • dna • p-glycoprotein • glutathione s-transferase
The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.,The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.
chemotherapy • drug resistance • dna • p-glycoprotein • glutathione s-transferase
Cancer Gene Therapy II
This article concludes an introduction to cancer gene therapy. There are three broad categories for applying gene therapy to cancer treatment: (1)restoring proper gene function, (2)stimulating the body's immune system to destroy the cancer, and (3)introduce a gene that converts an inactive drug into a toxic drug.
p53 • p21 • apoptosis • antisense • mutation
This article concludes an introduction to cancer gene therapy. There are three broad categories for applying gene therapy to cancer treatment: (1)restoring proper gene function, (2)stimulating the body's immune system to destroy the cancer, and (3)introduce a gene that converts an inactive drug into a toxic drug.
p53 • p21 • apoptosis • antisense • mutation
Do Tumor-Suppressors Promote Ageing?
The body utilizes tumor-suppressor proteins to inhibit cancer formation. Although this action would seem to increase longevity, and in many cases it does, paradoxically there are situations in which it may accelerate the ageing process.
tumor-suppressors • caretaker • gatekeeper • dna • senescence
The body utilizes tumor-suppressor proteins to inhibit cancer formation. Although this action would seem to increase longevity, and in many cases it does, paradoxically there are situations in which it may accelerate the ageing process.
tumor-suppressors • caretaker • gatekeeper • dna • senescence
Apoptosis
Apoptosis is programmed cell death in which damaged or defective cells commit suicide for the benefit of the body as a whole. This article provides a description of the process, how it fails to take place in cancer cells, and the latest research aimed in activating apoptosis to treat cancer.
apoptosis • bcl-2 • bax • p53 • caspase
Apoptosis is programmed cell death in which damaged or defective cells commit suicide for the benefit of the body as a whole. This article provides a description of the process, how it fails to take place in cancer cells, and the latest research aimed in activating apoptosis to treat cancer.
apoptosis • bcl-2 • bax • p53 • caspase
Bacterial toxins for the treatment of cancer
The use of live bacteria for the treatment of cancer has a long history, but problems with toxicity have limited its value in medicine. The field has recently been revitalized with the introduction of genetically modified bacteria, as well as the use of isolated toxins and proteins from the bacteria. These bacterial components are being studied individually and in combination with chemotherapeutic drugs in the treatment of cancer.
bacterial toxins • enterotoxins • diarrhea • tumor suppressor • p53
The use of live bacteria for the treatment of cancer has a long history, but problems with toxicity have limited its value in medicine. The field has recently been revitalized with the introduction of genetically modified bacteria, as well as the use of isolated toxins and proteins from the bacteria. These bacterial components are being studied individually and in combination with chemotherapeutic drugs in the treatment of cancer.
bacterial toxins • enterotoxins • diarrhea • tumor suppressor • p53
Targeting STAT Proteins for Cancer Therapy
Activation of STAT proteins by cancer cells has been shown to be an essential feature of cancer progression. A further understanding of the process can lead to novel methods of cancer therapy.
stat proteins • cytokine • tyrosine kinases • p53 • apoptosis
Activation of STAT proteins by cancer cells has been shown to be an essential feature of cancer progression. A further understanding of the process can lead to novel methods of cancer therapy.
stat proteins • cytokine • tyrosine kinases • p53 • apoptosis
Mouse Models in Cancer Research
The use of mouse models is an essential part of the drug development process. Much has been learned about the human cancer condition, and many drugs have been developed to treat cancer through testing with mice. However, the results of mouse studies should be treated with caution, and conclusions not drawn until human clinical trials are completed.
mouse models • genetic engineering • tumor progression • cancer research • human surrogates
The use of mouse models is an essential part of the drug development process. Much has been learned about the human cancer condition, and many drugs have been developed to treat cancer through testing with mice. However, the results of mouse studies should be treated with caution, and conclusions not drawn until human clinical trials are completed.
mouse models • genetic engineering • tumor progression • cancer research • human surrogates
Cancer Basics
A brief, lay description of the evolution of cancer in the body and the terminology necessary.
cells • mutations • genes • hyperplasia • dysplasia
A brief, lay description of the evolution of cancer in the body and the terminology necessary.
cells • mutations • genes • hyperplasia • dysplasia
Cancer Robustness
Robustness is the ability of cancers to adapt to changes in its environment and is a major cause of treatment failures. Viewing cancer as a robust system provides a more logical framework for the development of cancer therapies.
homeostasis • robustness • heterogeneity • feedback-control • multidrug resistance
Robustness is the ability of cancers to adapt to changes in its environment and is a major cause of treatment failures. Viewing cancer as a robust system provides a more logical framework for the development of cancer therapies.
homeostasis • robustness • heterogeneity • feedback-control • multidrug resistance
Audio Noise Measurement And Weighting Filters
Noise weighting compensates for the fact that the human ear does not have a flat frequency response. The variation in noise weighting curves can be confusing.
noise weighting • a-weighting • itu-r 468 • c-weighting • ccir 468
Noise weighting compensates for the fact that the human ear does not have a flat frequency response. The variation in noise weighting curves can be confusing.
noise weighting • a-weighting • itu-r 468 • c-weighting • ccir 468
Nutrition and Prostate Health
This article takes a quick glance at prostate health and alternative therapies to pharmaceutical drugs.
prostate • aging • ageing • health • men
This article takes a quick glance at prostate health and alternative therapies to pharmaceutical drugs.
prostate • aging • ageing • health • men
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