Articles related to "Apoptosis"
Apoptosis
Apoptosis is programmed cell death in which damaged or defective cells commit suicide for the benefit of the body as a whole. This article provides a description of the process, how it fails to take place in cancer cells, and the latest research aimed in activating apoptosis to treat cancer.
apoptosis • bcl-2 • bax • p53 • caspase
Apoptosis is programmed cell death in which damaged or defective cells commit suicide for the benefit of the body as a whole. This article provides a description of the process, how it fails to take place in cancer cells, and the latest research aimed in activating apoptosis to treat cancer.
apoptosis • bcl-2 • bax • p53 • caspase
Autoimmune Hemolytic Anemia
This article describes the symptoms, causes, diagnosis, disease course, and treatment of idiopathic or autoimmune hemolytic anemia (AIHA).
autoimmune • hemolytic • anemia • aiha • rbc
This article describes the symptoms, causes, diagnosis, disease course, and treatment of idiopathic or autoimmune hemolytic anemia (AIHA).
autoimmune • hemolytic • anemia • aiha • rbc
Micro-RNAs, Diseases and Therapy
Besides mediating between the DNA and proteins, RNA has a function in regulating the levels of proteins in the cell. This regulation is critical for the cell's behavior.
microrna • mirna • cancer • stem-cells • therapy
Besides mediating between the DNA and proteins, RNA has a function in regulating the levels of proteins in the cell. This regulation is critical for the cell's behavior.
microrna • mirna • cancer • stem-cells • therapy
Yeast Can Be Altruistic Too!
Programmed cell death for yeasts may save the organisms in times of severe stress just like altruitic people can save lives by giving up their own life.
yeast • apoptosis
Programmed cell death for yeasts may save the organisms in times of severe stress just like altruitic people can save lives by giving up their own life.
yeast • apoptosis
Cancer Treatment in Old Age
Cancer is largely a disease of older people. As a person ages, molecular, cellular, and physiological changes in the body influence the development of cancer. These factors also influence responses to treatment. Sociological factors also influence decisions to treat the older patient.
geriatric oncology • dna defects • mitochondria • reactive oxygen species • oxidative stress
Cancer is largely a disease of older people. As a person ages, molecular, cellular, and physiological changes in the body influence the development of cancer. These factors also influence responses to treatment. Sociological factors also influence decisions to treat the older patient.
geriatric oncology • dna defects • mitochondria • reactive oxygen species • oxidative stress
Nutrients for the Prevention of Colon Cancer
Although there are many causes of colon cancer, this article focuses on the role of calcium, vitamin D and folic acid in the prevention of this disease.
calcium • receptor protein • protein kinase c • apoptosis • vitamin d
Although there are many causes of colon cancer, this article focuses on the role of calcium, vitamin D and folic acid in the prevention of this disease.
calcium • receptor protein • protein kinase c • apoptosis • vitamin d
Oncolytic Viruses and Cancer Therapy
Oncolytic viruses are used to preferentially infect and kill cancer cells, while not harming normal tissues. Recent advances in virology and molecular biology have revitalized the field which now holds great promise.
oncolytic • virus • apoptosis • lysis • p53
Oncolytic viruses are used to preferentially infect and kill cancer cells, while not harming normal tissues. Recent advances in virology and molecular biology have revitalized the field which now holds great promise.
oncolytic • virus • apoptosis • lysis • p53
Proteasome Inhibitors for Cancer Therapy
Proteasomes are enzyme complexes responsible for the breakdown of regulatory proteins in the cell. These regulatory proteins are essential for the growth, survival and spread of cancer cells, so the proteasome is an attractive target for the development of new cancer drugs called proteasome inhibitors.
proteasome • regulatory proteins • transcription factors • apoptosis • angiogenesis
Proteasomes are enzyme complexes responsible for the breakdown of regulatory proteins in the cell. These regulatory proteins are essential for the growth, survival and spread of cancer cells, so the proteasome is an attractive target for the development of new cancer drugs called proteasome inhibitors.
proteasome • regulatory proteins • transcription factors • apoptosis • angiogenesis
Resistance to Anticancer Drugs-1
The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.,The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.
chemotherapy • drug resistance • dna • p-glycoprotein • glutathione s-transferase
The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.,The development of resistance to anticancer drugs is a major failure in cancer therapies. This article examines the reasons for this phenomenon.
chemotherapy • drug resistance • dna • p-glycoprotein • glutathione s-transferase
The AIDS Virus Kills the Killer Cells
Why people with HIV infection suddenly develop AIDS.
aids hiv cd4 cd8 white blood cells cxcr4 virus mut
Why people with HIV infection suddenly develop AIDS.
aids hiv cd4 cd8 white blood cells cxcr4 virus mut
ALPS: Lymphoproliferative Syndrome
Autoimmune lymphoproliferative syndrome (ALPS) is characterized by an enlarged spleen, thrombocytopenia, and other autoimmune disorders, usually AIHA.
autoimmune • autoimmune disorder • lymphoproliferative • autoimmune lymphoproliferative syndrome • alps
Autoimmune lymphoproliferative syndrome (ALPS) is characterized by an enlarged spleen, thrombocytopenia, and other autoimmune disorders, usually AIHA.
autoimmune • autoimmune disorder • lymphoproliferative • autoimmune lymphoproliferative syndrome • alps
Do Tumor-Suppressors Promote Ageing?
The body utilizes tumor-suppressor proteins to inhibit cancer formation. Although this action would seem to increase longevity, and in many cases it does, paradoxically there are situations in which it may accelerate the ageing process.
tumor-suppressors • caretaker • gatekeeper • dna • senescence
The body utilizes tumor-suppressor proteins to inhibit cancer formation. Although this action would seem to increase longevity, and in many cases it does, paradoxically there are situations in which it may accelerate the ageing process.
tumor-suppressors • caretaker • gatekeeper • dna • senescence
Resistance to Anticancer Drugs-2
This article describes the latest research in the develpment of drugs to overcome resistance to anticancer drugs
mdr-1 • p-glycoprotein • valspodar • bioflavonoids • cinchonine
This article describes the latest research in the develpment of drugs to overcome resistance to anticancer drugs
mdr-1 • p-glycoprotein • valspodar • bioflavonoids • cinchonine
Curcumin Triggers Cancer Cell Death
Many cancer patients would chose alternative medicine instead of conventional cancer drugs. This new finding offers a potential alternative to traditional intervention.
curcumin longa - a chemoprotective agent • apoptosis • esophageal cancer • causes of esophageal cancer • preventative measures against oral cancer
Many cancer patients would chose alternative medicine instead of conventional cancer drugs. This new finding offers a potential alternative to traditional intervention.
curcumin longa - a chemoprotective agent • apoptosis • esophageal cancer • causes of esophageal cancer • preventative measures against oral cancer
Honokiol
A compound found in magnolia species holds exciting promise in the management of anxiety, cancer, and other challenging conditions.
cancer • honokiol • magnolia • magnoliol • magnolia officinalis
A compound found in magnolia species holds exciting promise in the management of anxiety, cancer, and other challenging conditions.
cancer • honokiol • magnolia • magnoliol • magnolia officinalis
Vitamin D Impairs Low Level Radiation
Bioactive vitamin D is known for its role in skeletal health. Researchers claim it may also protect against low-level or background radiation.
25 dihydroxyvitamin d3 • low-level/background radiation • cellular differentiation • apoptosis • cancer
Bioactive vitamin D is known for its role in skeletal health. Researchers claim it may also protect against low-level or background radiation.
25 dihydroxyvitamin d3 • low-level/background radiation • cellular differentiation • apoptosis • cancer
Weed Killer Kills Fertility
Until recently scientists thought that pesticides did not have any affect on reproductive health. But animal studies suggest that we may be at risk after all.
weed killers kill fertility • fertilizer and infertility • agro-chemicals and infertility • autoimmunity • low sperm count
Until recently scientists thought that pesticides did not have any affect on reproductive health. But animal studies suggest that we may be at risk after all.
weed killers kill fertility • fertilizer and infertility • agro-chemicals and infertility • autoimmunity • low sperm count
Cancer Gene Therapy II
This article concludes an introduction to cancer gene therapy. There are three broad categories for applying gene therapy to cancer treatment: (1)restoring proper gene function, (2)stimulating the body's immune system to destroy the cancer, and (3)introduce a gene that converts an inactive drug into a toxic drug.
p53 • p21 • apoptosis • antisense • mutation
This article concludes an introduction to cancer gene therapy. There are three broad categories for applying gene therapy to cancer treatment: (1)restoring proper gene function, (2)stimulating the body's immune system to destroy the cancer, and (3)introduce a gene that converts an inactive drug into a toxic drug.
p53 • p21 • apoptosis • antisense • mutation
Cancer Stem Cells
Cancer stem cells constitute only a very small portion of tumors yet play a key role in the proliferation of cancer. Cancer stem cells may be inherently resistant to chemotherapeutic drugs. Cancers that result from chronic tissue injury may be due to excessive activation of stem cells.
stem cells • cancer stem cells • apoptosis • wnt • shh
Cancer stem cells constitute only a very small portion of tumors yet play a key role in the proliferation of cancer. Cancer stem cells may be inherently resistant to chemotherapeutic drugs. Cancers that result from chronic tissue injury may be due to excessive activation of stem cells.
stem cells • cancer stem cells • apoptosis • wnt • shh
Targeting STAT Proteins for Cancer Therapy
Activation of STAT proteins by cancer cells has been shown to be an essential feature of cancer progression. A further understanding of the process can lead to novel methods of cancer therapy.
stat proteins • cytokine • tyrosine kinases • p53 • apoptosis
Activation of STAT proteins by cancer cells has been shown to be an essential feature of cancer progression. A further understanding of the process can lead to novel methods of cancer therapy.
stat proteins • cytokine • tyrosine kinases • p53 • apoptosis
The p53 tumor suppressor gene
The p53 gene performs an essential function in its normal role as a tumor suppressor. However, it is found in a mutated form in over half of all types of cancers. A fuller understanding of p53’s activities can lead to novel approaches to cancer treatment.
p53 • tumor suppressor • oncogene • dna • p21 protein
The p53 gene performs an essential function in its normal role as a tumor suppressor. However, it is found in a mutated form in over half of all types of cancers. A fuller understanding of p53’s activities can lead to novel approaches to cancer treatment.
p53 • tumor suppressor • oncogene • dna • p21 protein
Black Cumin Seed May Help Fight Cancer
Black cumin seed is a potent herb with powerful anti-oxidant properties. Laboratory research has revealed that this herb may be effective in combating some cancers.
cancer • cancer research • cumin • black cumin • cumin seed
Black cumin seed is a potent herb with powerful anti-oxidant properties. Laboratory research has revealed that this herb may be effective in combating some cancers.
cancer • cancer research • cumin • black cumin • cumin seed
Nutrition and Prostate Health
This article takes a quick glance at prostate health and alternative therapies to pharmaceutical drugs.
prostate • aging • ageing • health • men
This article takes a quick glance at prostate health and alternative therapies to pharmaceutical drugs.
prostate • aging • ageing • health • men
Broccoli Fights Cancer
Previous studies have established that Indole-3-Carbinol (I3C) prevents cancer. This new study shows how I3C prevents the development and progression of carcinoma.
cancer protective functions of indole-3-carbinol • broccoli and cruciferous vegetables and cancer • estrogen receptor positive breast cancer • estrogen receptor negative breast cancer • apoptosis of cancer cells
Previous studies have established that Indole-3-Carbinol (I3C) prevents cancer. This new study shows how I3C prevents the development and progression of carcinoma.
cancer protective functions of indole-3-carbinol • broccoli and cruciferous vegetables and cancer • estrogen receptor positive breast cancer • estrogen receptor negative breast cancer • apoptosis of cancer cells
Fun Cell Biology Education
Studying cell biology doesn't have to suck. Here's a fun and fascinating summary of how the cells of your body work to keep you alive and healthy.
fun interesting cell biology education • fun interesting human biology education • cell biology not boring • cell biology does doesn't suck sucks • summary how cells work
Studying cell biology doesn't have to suck. Here's a fun and fascinating summary of how the cells of your body work to keep you alive and healthy.
fun interesting cell biology education • fun interesting human biology education • cell biology not boring • cell biology does doesn't suck sucks • summary how cells work
Indirubin
Indirubin is the active ingredient in a Chinese herbal medicine used to treat chronic myelocytic leukemia. Researchers have determined how this compound and its derivatives exert their effects against various cancers.
indirubin • myelocytic leukemia • indirubin-5-sulfonate • indirubin-3-monoxime • stat3
Indirubin is the active ingredient in a Chinese herbal medicine used to treat chronic myelocytic leukemia. Researchers have determined how this compound and its derivatives exert their effects against various cancers.
indirubin • myelocytic leukemia • indirubin-5-sulfonate • indirubin-3-monoxime • stat3
White Button Mushrooms (Agaricus bisporus)
Conventional wisdom suggests that lightly colored vegetables offer "low" or no nutrients. Research shows white mushrooms contain many nutrients that confer health.
common white button mushroom • health benefits of mushrooms • chemoprotective substances • immune-enhancing substances • breast cancer
Conventional wisdom suggests that lightly colored vegetables offer "low" or no nutrients. Research shows white mushrooms contain many nutrients that confer health.
common white button mushroom • health benefits of mushrooms • chemoprotective substances • immune-enhancing substances • breast cancer
External Tumors in Dogs and Cats
Tumors have been burned away by black salves and cut out by knives for centuries. In pets, new and old solutions compete for success.
external tumors in dogs and cats • treating cancer with neoplasene • skin cancer in cats • bone cancer in dogs • black salve
Tumors have been burned away by black salves and cut out by knives for centuries. In pets, new and old solutions compete for success.
external tumors in dogs and cats • treating cancer with neoplasene • skin cancer in cats • bone cancer in dogs • black salve
Causes and Treatments of PD
Find out why dopamine-producing cells die in patients with PD, and how preventing this from happening is the current focus of therapy targets
causes of parkinson’s • treating parkinson’s • preventing parkinson’s • genetic factors in parkinson's • oxidative stress and parkinson's
Find out why dopamine-producing cells die in patients with PD, and how preventing this from happening is the current focus of therapy targets
causes of parkinson’s • treating parkinson’s • preventing parkinson’s • genetic factors in parkinson's • oxidative stress and parkinson's
Inflammation Causes Cancer Weight Loss
Recognition that the loss of appetite and weight loss associated with cancer is a result of cancer-induced inflammation, may provide therapeutic approaches.
cancer weight loss • cancer cachexia • cancer anorexia • cancer symptom • cancer inflammation
Recognition that the loss of appetite and weight loss associated with cancer is a result of cancer-induced inflammation, may provide therapeutic approaches.
cancer weight loss • cancer cachexia • cancer anorexia • cancer symptom • cancer inflammation
Obesity and Cancer
Recent studies have shown conclusively the influence of excess body weight on the increased risk of death from a large variety of cancers.
epidemiological studies • obesity • body-mass index • cancer types • insulin
Recent studies have shown conclusively the influence of excess body weight on the increased risk of death from a large variety of cancers.
epidemiological studies • obesity • body-mass index • cancer types • insulin
Use of Human Milk as Cancer Therapy
The use of human breast milk as an alternative therapy for cancer patients can reduce symptoms of disease and improve patient quality of life.
improve cancer symptoms • reduce chemotherapy side effects • human milk and cancer • breast milk and cancer • human milk kills cancer
The use of human breast milk as an alternative therapy for cancer patients can reduce symptoms of disease and improve patient quality of life.
improve cancer symptoms • reduce chemotherapy side effects • human milk and cancer • breast milk and cancer • human milk kills cancer
Cancer Drugs that Inhibit Epidermal Growth Factor Receptors
Epidermal growth factor receptors are found in the cell membranes. When activated, these receptors initiate a signaling process that regulates cell growth. Since many cancers have excessive activation of these receptors, drugs have been developed to inhibit their functioning.
epidermal growth factor receptors • cell signaling • epidermal growth factor • transforming growth factor alpha • monoclonal antibodies
Epidermal growth factor receptors are found in the cell membranes. When activated, these receptors initiate a signaling process that regulates cell growth. Since many cancers have excessive activation of these receptors, drugs have been developed to inhibit their functioning.
epidermal growth factor receptors • cell signaling • epidermal growth factor • transforming growth factor alpha • monoclonal antibodies
Lymphoma and the Immune System
Have you or someone you know been diagnosed with lymphoma? Understand the mechanics, diagnosis, and treatment of lymphoma.
lymphoma • b cell lymphoma • t cell lymphoma • lymphoma treatment • symptoms lymphoma
Have you or someone you know been diagnosed with lymphoma? Understand the mechanics, diagnosis, and treatment of lymphoma.
lymphoma • b cell lymphoma • t cell lymphoma • lymphoma treatment • symptoms lymphoma
Colon Cancer Stopped by Lipoxins and Resolvins
Aspirin modifies COX-2 in colon cancer cells and provides anti-tumorigenic effects. Modified COX-2 produces anti-inflammatory lipoxins and resolvins to block cancer.
cancer treatment • aspirin • omega-6 oil • omega-3 fish oil • nfkappab
Aspirin modifies COX-2 in colon cancer cells and provides anti-tumorigenic effects. Modified COX-2 produces anti-inflammatory lipoxins and resolvins to block cancer.
cancer treatment • aspirin • omega-6 oil • omega-3 fish oil • nfkappab
Low Dose Naltrexone Update
Mounting evidence shows that LDN offers more than a promise. At the 3rd Annual LDN Conference, researchers gathered to share their latest findings.
inflammation • oxidative stress • naltrexone • low dose naltrexone • ldn
Mounting evidence shows that LDN offers more than a promise. At the 3rd Annual LDN Conference, researchers gathered to share their latest findings.
inflammation • oxidative stress • naltrexone • low dose naltrexone • ldn
Mitochondria, Power Plants of the Cell
Mitochondria provide all of the energy for a cell, making them some of the most important organelles in the cell.
mitochondrial dna • mitochondrial genetics • functions of mitochondria • power plants of the cell • what mitochondria look like
Mitochondria provide all of the energy for a cell, making them some of the most important organelles in the cell.
mitochondrial dna • mitochondrial genetics • functions of mitochondria • power plants of the cell • what mitochondria look like
Statin Induced Myopathy
The use of statins has greatly increased to over 100 million prescriptions per year since they were introduced for the treatment of high cholesterol in 1987.
statins • myopathy • creatinine kinase • cholesterol • hyperlipidemia
The use of statins has greatly increased to over 100 million prescriptions per year since they were introduced for the treatment of high cholesterol in 1987.
statins • myopathy • creatinine kinase • cholesterol • hyperlipidemia
Avocado (Persea gratissima, Persea americana)
Dubbed "butter" pear,unassuming, and once reserved for the elite - avocado has taken center stage as a Superfruit for its epicurean flavor and proven health benefits.
avocado/butter pear • persea americana • heart-healthy • anti-cancer • antidiabetic
Dubbed "butter" pear,unassuming, and once reserved for the elite - avocado has taken center stage as a Superfruit for its epicurean flavor and proven health benefits.
avocado/butter pear • persea americana • heart-healthy • anti-cancer • antidiabetic
Chlorella Algae, Nutrition Supplement Superfood
This tiny algae almost too small to see has some of the highest nutrient and vitamin contents and may help fight a wide range of diseases.
chlorella • algae • health • nutrition • nutritional supplements
This tiny algae almost too small to see has some of the highest nutrient and vitamin contents and may help fight a wide range of diseases.
chlorella • algae • health • nutrition • nutritional supplements
Excessive Fat-Soluble Vitamins
Pregnant women should be aware that over-dosage of certain vitamins may present a potential risk to the fetus' developing organ systems, especially the brain.
fat-soluble vitamins • excessive fat-soluble vitamins • overdose of vitamin d • overdose of vitamin a • over-dosage of vitamins
Pregnant women should be aware that over-dosage of certain vitamins may present a potential risk to the fetus' developing organ systems, especially the brain.
fat-soluble vitamins • excessive fat-soluble vitamins • overdose of vitamin d • overdose of vitamin a • over-dosage of vitamins
Fruit and Vegs Deter Lung Cancer
Over 90 percent of lung cancer is caused by cigarette smoking. However, three servings of fresh fruit and vegetables a day may protect smokers' lungs from carcinogens.
fruit and vegs deter lung cancer • bioflavonoids help smokers protect their lungs • flavonoids and a reduced risk of lung cancer • ucla study into smokers’ diets and flavonoids • flavonoids’ cancer protection
Over 90 percent of lung cancer is caused by cigarette smoking. However, three servings of fresh fruit and vegetables a day may protect smokers' lungs from carcinogens.
fruit and vegs deter lung cancer • bioflavonoids help smokers protect their lungs • flavonoids and a reduced risk of lung cancer • ucla study into smokers’ diets and flavonoids • flavonoids’ cancer protection
Graves' Disease Revisited
Graves' disease is a self-limited autoimmune hyperthyroid disorder caused by a combination of genes and environmental triggers.
graves disease • autoimmune • thyroid • environmental triggers • tsi
Graves' disease is a self-limited autoimmune hyperthyroid disorder caused by a combination of genes and environmental triggers.
graves disease • autoimmune • thyroid • environmental triggers • tsi
Green Tea May Help Prevent Prostate Cancer
Drinking Green Tea may be an easy way to prevent prostate cancer. Multiple studies have shown promising results.
prevent prostate cancer • green tea prevents prostate cancer • cancer prevention • green tea benefits • prostate cancer and green tea
Drinking Green Tea may be an easy way to prevent prostate cancer. Multiple studies have shown promising results.
prevent prostate cancer • green tea prevents prostate cancer • cancer prevention • green tea benefits • prostate cancer and green tea
Health Benefits of Ginger
For over 5000 years, ginger has been used for its medicinal and healing properties. Incorporate this spicy rhizome in your daily diet and keep diseases at bay.
ginger and nausea • ginger and cancer • ginger for colds • ginger and cholesterol • ginger for pregnancy
For over 5000 years, ginger has been used for its medicinal and healing properties. Incorporate this spicy rhizome in your daily diet and keep diseases at bay.
ginger and nausea • ginger and cancer • ginger for colds • ginger and cholesterol • ginger for pregnancy
Healthy Spices that Fight Cancer
Many herbs and spices have been long recognized to help prevent cancer. Here are a few that scientists have discovered really work.
spices that fight cancer • herbs and spices anti-cancer properties • oregano fights cancer • jalapenos anti-cancer • rosemary and cancer
Many herbs and spices have been long recognized to help prevent cancer. Here are a few that scientists have discovered really work.
spices that fight cancer • herbs and spices anti-cancer properties • oregano fights cancer • jalapenos anti-cancer • rosemary and cancer
Nutritional Genomics - Personalized Nutrition
There is a lot of truth in the old adage "you are what you eat." Nutrigenomics, investigates the interaction between nutrients and genes and how they are manifested.
nutritional genomics/nutrigenomics • bioactive food components • antioxidants • transcription factors • molecules that promote inflammation
There is a lot of truth in the old adage "you are what you eat." Nutrigenomics, investigates the interaction between nutrients and genes and how they are manifested.
nutritional genomics/nutrigenomics • bioactive food components • antioxidants • transcription factors • molecules that promote inflammation
Oregano
The mighty antioxidants in oregano and the vital oils in oregano volatile oil make this herb stand out.
oregano culinary delight • oregano versatile essential oil • oregano mighty antioxidants • oregano volatile oil • oregano and marjoram
The mighty antioxidants in oregano and the vital oils in oregano volatile oil make this herb stand out.
oregano culinary delight • oregano versatile essential oil • oregano mighty antioxidants • oregano volatile oil • oregano and marjoram
Sophora Flavescens
Sophora flavescens is a frequently prescribed herb in traditional Chinese Medicine. Modern research has substantiated many of its traditional uses.
cancer • herbal treatment for cancer • alternative treatment for breast cancer • herbal treatment for inflammation • chinese medicine for cancer
Sophora flavescens is a frequently prescribed herb in traditional Chinese Medicine. Modern research has substantiated many of its traditional uses.
cancer • herbal treatment for cancer • alternative treatment for breast cancer • herbal treatment for inflammation • chinese medicine for cancer
Statins and Autoimmune Diseases
Within the last few years, several published reports have linked statins to lupus and other auotimmune disorders; learn about the benefits and risks of statin therapy.
statins • lipid-lowering agents • cholesterol • cholesterol-lowering agents • atherosclerosis
Within the last few years, several published reports have linked statins to lupus and other auotimmune disorders; learn about the benefits and risks of statin therapy.
statins • lipid-lowering agents • cholesterol • cholesterol-lowering agents • atherosclerosis
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