Resistance to Anticancer Drugs-2
drug resistance is provided in a paper by Song and associates. 7They found that elevated levels of fibroblast growth factors found in the extracellular fluid (outside the cells) caused increased resistance to chemotherapeutic drugs, and that an inhibitor of these growth factors (suramin) restored sensitivity to these drugs. These results could provide a basis for designing new treatment strategies.
REFERENCES
1. Brown, JM. Hypoxic cytotoxic agents: a new approach to cancer chemotherapy. Drug Resist Updat. Feb 3 (1): pages 7-13 (2000) 2.Lie,Jie and associates. Reversal effects of nomegesterol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line. Breast Cancer Res, Vol 3, pages 253-263 (2001) BioMed Central 3.Leslie, EM and associates. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and ATPase activities by interaction with dietary flavonoids. Mol Pharmacol May Vol 59 (5) pages 1171-80 (2001) 4.Li, Y and associates. Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells. Mol Med Dec. Vol 6 (12), pages 1008-15 (2000) 5.Nagata, J and associates. Reversal of cisplatin and multidrug resistance by ribozyme-mediated guutathione suppression.
Biochem Biophys Res Commun, Aug 17, Vol 286 (2), pages 406-13 (2001) 6.Ohi, Y and associates. Overcoming of multidrug resistance by introducing the apoptosis gene, bcl-Xs, into MRP-overexpressing drug resistant cells. Int J Oncol, May Vol 16 (5), pages 959-69 (2000) 7.Song, S and associates. Fibroblast growth factors: An epigenic mechanism of broad-spectrum resistance to anticancer drugs. PubMed Central 8.Von Hoff, DD. The taxoids: same roots, different drugs. Semin Oncol Aug Vol 24 (4 Suppl 13): S13 (1997)
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