Mouse Models in Cancer Research - Page 3

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Page 3

Nov 1, 2005

Summary

The use of mouse models is an essential part of the drug development process. Much has been learned about the human cancer condition, and many drugs have been developed to treat cancer through testing with mice. However, the results of mouse studies should be treated with caution, and conclusions not drawn until human clinical trials are completed.

References

1. Anisimov V., et al. Cancer in rodents: does it tell us about cancer in humans? Nature Reviews Cancer. 2005 Oct; 5 (10): 807-819.

2. Bolon B. Genetically engineered animals in drug discovery and development: a maturing resource for toxicologic research. Basic & Clinical Pharmacology & Toxicology. 2004; 95: 154-161.

3. Frijhoff A., et al. Advances in molecular carcinogenesis: current and future use of mouse models to screen and validate molecularly targeted anticancer drugs. Wiley-Liss, Inc. 2004.

4. Hahn W, Weinberg R. Modeling the molecular circuitry of cancer. Nature REviews Cancer. 2002 May; 2 (5): 331-341.

5. National Cancer Institute. Drug Discovery at the National Cancer Institute: Questions and Answers

6. Rangarajan A, Weinberg R. Comparative biology of mouse versus human cells: modeling human cancer in mice. Nature Reviews Cancer. 2003 Dec; 3 (12): 952-959.

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