Detecting Cancer with Autoantibodies

Duke University researchers 4have uncovered many autoantibodies to breast cancer, and many others have been found through the SEREX procedure described below. These findings await clinical studies.

Other cancers

The SEREX laboratory technique 5)has resulted in the compilation of large libraries of antigens associated with cancers. These include cancers of the esophagus, colon, stomach, kidneys, lung, breast, prostate, liver, and ovary, melanoma, sarcoma, neuroblastoma, Hodgkins and non-Hodgkins lymphoma, and leukemia. Although the SEREX technique is not useful for screening, it is an important information resource for further studies.

References

1. Chinnaiyan A. Autoantibody signatures for prostate-cancer detection. New England J Med. 2005 Sept 22; 353 (12): 1224-1235.

2. Finn O. Immune response as a biomarker for cancer detection and a lot more. New England J Med. 2005 Sept 22; 353 (12): 1288-1290.

3. Metcalfe S, et al. p53 autoantibodies in 1006 patients followed up for breast cancer. Breast Cancer Res. 2000; 2: 438-443.

4. Ochs R. Autoantibodies in breast cancer. Schilling Research Conference on Hormones and Cancer. Sept. 18-21, 1997.

5. Serex Review. Cancer Immunity. J Academy Cancer Immunology. March 2004.

6. Tan E. Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis. J Clin Investig 2001; 108 (10): 1411-1415.

Go To Page: 1 2