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The cyclooxygenase 2 (COX-2) enzyme is commonly overexpressed in colorectal tumors. The formation of this enzyme is directed by COX-2 messenger RNA. A group of researchers devised a fecal COX-2 messenger RNA assay, and found a 90% sensitivity in detecting colorectal cancer. Although promising, fecal DNA or RNA testing is still in the early stages of development.
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