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Colorectal Cancer Screening - Page 3


© David Olle
Page 3

Mar 31, 2005


The cyclooxygenase 2 (COX-2) enzyme is commonly overexpressed in colorectal tumors. The formation of this enzyme is directed by COX-2 messenger RNA. A group of researchers devised a fecal COX-2 messenger RNA assay, and found a 90% sensitivity in detecting colorectal cancer. Although promising, fecal DNA or RNA testing is still in the early stages of development.

References

1. Collins, JF, et.al. Accuracy of screening for fecal occult blood on a single stool sample obtained by digital rectal examination: a comparison with recommended sampling practice. Ann. Int. Med. 2005 Jan 18; 142 (2): 81-5.

2. Fletcher, RH. The end of barium enemas? New Eng. J. Med. 2000 June 15; 342 (24): 1823-4.

3. Hurlstone, DP. et.al. Colonoscopic resection of lateral spreading tumors: a prospective analysis of endoscopic mucosal resection. Gut. 2004; 53: 1334-39.

4. Kanaoka, S. et al. Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology. 2004 Aug; 127 (2): 422-7.

5. Lenhart, K. et.al. Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin. Gastroenterol. Hept. 2005 Feb; 3(2)

6. Muller HM. Methylation changes in faecal DNA: a marker for colorectal cancer screening? Lancet. 2004 Apr. 17; 363 (9417): 1283-5.

7. Osborn, NK, and Ahlquist, DA. Stool screening for colorectal cancer: molecular approaches. Gastroenterology. 2005 Jan; 128: 192-206.

8. Pickhardt PJ. et. al. Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. New Eng. J. Med. 2003 Dec. 4; 349 (23): 2191-2200.

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Another greatly researched nutrient for helping prevent cancer is Garlic. One of many studies was done at the Department of Epidemiology and Nutrition, at the University of North Carolina at ...

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