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Improving Drug Delivery to Tumors - Page 2


© David Olle
Page 2

Nov 30, 2004


Other compounds under study

Several other compounds have been shown to lower tumor interstitial fluid pressure, but further study is necessary to demonstrate that they can increase drug uptake. They include transforming growth factor beta antagonists, hyaluronidase, dexamethazone, and nicotinamide (a vitamin derivative).

References

1. Heldin C, Rubin K, Pietras K and Ostman A. High Interstitial Fluid Pressure - An Obstacle in Cancer Therapy. Nature Reviews Cancer. 2004 Oct; 4 (10): 806-813.

2. Milosevec M, Fyles A, et al. Interstitial Fluid Pressure Predicts Survival in Patients with Cervix Cancer Independent of Clinical Prognostic Factors and Tumor Oxygen Measurements. Cancer Research. 2001 Sept 1; 61: 6400-6405.

3. Rubin K. Molecular Biology of the Tumor Stroma- a Target for Novel Therapy. Uppsala University- Sweden. 2002-2004.

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