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Proteomics for Cancer Detection - Page 2

© David Olle

Studies on cancer detection using proteomics 3 4)

Ovarian cancer - An early detection method for this cancer is vitally important, as ovarian cancer is usually not detected until it is too late. Studies at the University of California found that proteomic procedures distinguished between benign and malignant ovarian conditions with an accuracy of over 85%.

Lung cancer - Three types of microchips were evaluated for usefulness in detecting lung cancer. Preliminary results revealed a protein that was enriched 5-fold to 10-fold in lung cancer cells.

Colorectal cancer - Researchers used protein microchips in an attempt to understand the variability in response of cancer patients to treatment with nonsteroidal anti-inflammatory drugs, such as Celecoxib. Preliminary results indicate that protein signatures can be related to clinical outcome following chemoprevention treatment.

Endometrial cancer - Researchers evaluated protein chips in an attempt to detect early-stage endometrial cancer. They found that ten proteins were overexpressed in endometrial cancer compared to normal tissues.

References

1. Protein Chips Offer Powerful Method for Probing Protein Function. Howard Hughes Medical Institute, Sept. 8, 2000.

2. Lane, Laura. Protein Microarrays at the Cusp. The Scientist, Vol. 17, Issue 14, July 14, 2003.

3. Mariani, S. Clinical Proteomics: New Promises for Early Cancer Detection. Medscape General Medicine, Vol. 5, No. 2, 2003

4. Mitchell, S. Proteomics Improving Cancer Detection. United Press International, Nov. 19, 2003.

5. Wu, W., Hu, W. and Kavanagh, J. Proteomics in Cancer Research. Int. J. Gynecol. Res. Vol. 12, pp. 409-423, 2002

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