Elmiron


© Lisa Griggs
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In September of 1996, the Food and Drug Administration approved a new medication for use in treating Interstitial Cystitis. Elmiron (pentosan polysulfate sodium) is currently the only oral medication to be approved specifically for IC. Since its introduction such a short time ago, Elmiron has become one of the most commonly used oral treatments for IC.

Elmiron comes in capsule form. The usual dose is 100mg three times each day, for a total of 300mg daily. Elmiron should normally be taken one hour before meals, or at least 2 hours after meals for maximum effectiveness. In FDA clinical trials, 38% of patients reported at least some improvement in their symptoms within three months. In some cases, it may take longer (possibly up to 12 months) before the patient notices any significant improvement.

Although the way Elmiron works is not known, it is generally believed that it protects the bladder by restoring the lining. Elmiron may actually coat the inside of the bladder, acting as a replacement for the thin, damaged bladder lining. The Elmiron coating may prevent urine, bacteria, and other irritants from penetrating the lining. These irritants can lead to inflammation of the muscle tissue, causing tremendous pain. Patients are usually advised to continue Elmiron treatment for the duration of their lives, or until a cure for Interstitial Cystitis is found.

Elmiron has been shown to greatly reduce pain in many patients, especially when used in combination with other treatments. No drug interactions have yet been reported, but it is important that your doctor knows exactly which medications you are taking. Elmiron is available only by prescription. Your physician can determine whether you should consider this treatment.

Patients taking Elmiron report few side effects. They are mild and infrequent, and also reversible when the drug is discontinued. Some possible side effects include headache, rash, diarrhea, abdominal pain, dizziness, and mild hair loss. Notify your physician if you experience any side effects.

If you would like more information about Elmiron, visit the following sites:

http://www.elmiron100.com

http://www.thehealthconnection.com/NewDr...

http://www.ichelp.org/TreatmentsandSelfH...

http://cponline.gsm.com

For information about Elmiron and/or Interstitial Cystitis, call the IC Info Line's toll-free number 1-800-HELP ICA (1-800-435-7422)

Other oral medications are also used to help alleviate the pain associated with IC. Antihistamines are sometimes used, and are especially helpful for those patients who also suffer from recurring allergies. Hydroxyzine (Atarax, Vistaril) is the most common antihistamine used in treating IC. Tricyclic antidepressants, prescribed in low doses, can also be beneficial. It is thought that they interfere with pain impulses, causing the brain to ignore them.

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