Final Conclusion of Research Part 2

your basically at a point where it's worth a shot, so take it or leave it.   The conventional medications listed below are the one's "I" will have to reduce, but yours may be similar. Your Dr. can assist you with this or make calls to the people listed if he has questions.   E-mail me back with your feelings, ideas, or questions on this as I know you'll have many.   Anti-mycrobial Regimen

Duration of treatment is unknown.  Follow for 36 months - review at that time! Stop 1ml per/week Methotrexate Injection immediately when beginning Anti-Mycrobial treatment. Stop 20mg's per/day of Prednisone by decreasing 5m'g per week  6-12 weeks into Anti-Mycrobial treatment Stop 3,600mg's of Asocol 6-8 months into Anti-Mycrobial treatment Don't Stop Centrum supplements or multivitamins while on Anti-Mycrobial treatment Don't Stop Calcium while on Anti-Mycrobial treatment

Rifabutin 300mg's to start, then go to - 450mg at 1 month (Mycobutin, Pharmacia & Upjohn), -(ansamycin)A derivative of rifamycin-S. An oral drug approved by the FDA for preventing MAC in people with AIDS and CD4 cell counts of less than 75. Rifabutin is also used in combination with other drugs for the treatment of active MAC infection. Possible side effects include neutropenia, eye and muscle irritation and a brown-orange discoloration of skin and urine.

Clarithromycin 250mg's twice per day then go 250mg's + 500mg's at 1 month (Biaxin/Klacid/Klaricid, Abbott Laboratories) A derivative of natural erythromycins and the azalide azithromycin.  An antibiotic approved for the treatment of MAC and also used for preventing this disease in people with AIDS. Side effects include diarrhea, nausea and abnormal taste. Clarithromycin may cause severe abdominal pain at high doses.

Clofazimine 50mg twice per day (Lamprene, Novartis). An antileprosy agent sometimes administered in combination with other drugs to treat MAC. Possible side effects include gastrointestinal upset, skin discoloration and rashes.

Ethambutol 4-5-6 week 15mg/kg divided into twice daily regimen. Optic nerve damage is possible, and visual field acuity must be tested,  every 4 months.   An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect.

 Monitor: FBC, ESR, LFT's, CRP, Ferritin + Iron studies;  Colonoscopy + biopsy; cross-sectional U/S to measure thickness of small bowel(ileum) if originally thickened. Culture of MAP at Shafran's establishment as well as whatever is abnormal in your blood currently. (End Anti-Paratuberculosis anti-biotic regimen, and suggestions)

(The Miracle)

    The anti-biotic treatment is a "tough" route to follow, but does provide excellent results.  It's

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