BENEFIT of FLAXSEED?
This piece appeared in the recent Breast Cancer Action newsletter. This organization is concerned about environmental issues and doesn't back down when they have a tough question. Check it out at www.bcaction.org
Flaxseed (also referred to as linseed) is a good source of protein, fiber, and omega-3 fatty acids. It is also a rich source of lignans, which are plant compounds with estrogen-like qualities that may interfere with the production of estrogen. Though research is conflicting, some previous studies have shown a reduction in the growth of tumors in rats fed with flaxseed. A recent study has examined the effects of dietary flaxseed, ingested through muffins, on tumor markers in women with breast cancer. The study reported a reduction in two markers used to measure tumor growth. The study survey was a small group of 19 women, but the researchers hope to expand the study to look at larger groups. Although this study is too small to draw any conclusions on the success of flaxseed in reducing tumors, flaxseed is known to be good for your health for other reasons and is relatively free from negative side effects. Flaxseed is available in the form of flour, meal, and oil, and can be found in many health food stores.
AROMATASE INHIBITORS and BONE LOSS
A recent article in the Journal of Clinical Oncology (Volume 23, No 22, 8/1/05) talks about the use or aromatase inhibitors the potential bone loss.
A brief paraphrase of the abstract:
Osteoporosis (bone loss) was the concern of endocrinologists. Due to the potential for bone loss related to cancer treatments, the American Society of Clinical Oncology Task Force has charged medical oncologists with an active role in assessing a woman's bone loss and preventing loss. Estrogen protects against bone loss. Menopause, chemotherapy and aromatase inhibitors aid bone resorption and bone loss may occur.
While aromatase inhibitors are acknowledged as better in treating metastatic disease, there is concern about their long-term affect on health. Tamoxifen may act as a weak estrogen and preserve bone density. A recent controlled trial of exemestane (a steroidal irreversible inhibitor) showed a protective effect on bone.
It is commendable that they are studying the potential side effects of aromatase inhibitors. Postmenopausal women are encouraged to use supplemental calcium and Vitamin D, reduce smoking, increase physical activity and have their BMD measured periodically. Women using aromatase inhibitors should receive bisphosphonates according to published guidelines.
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