There have been studies which show that some of the activity of these medications is mediated by their antifoliate action. It has also been shown that seizures cause a decrease in total brain folate content. Suggesting that folate metabolisim is in some way linked to the epileptic process. At this time it is not known how and still being studied.
A supplement of folic acid is strongly reccommened for pregnant women while on anti-convulsants.It has been proven to help protect against birth defects. Adding this supplement is a way to ensure that you will get adequet intakes. It is preferable that you do so under a physicians or nutritionist care.This is to ensure that you will have correct dosing and periodic blood levels taken. It will usually take several weeks to months before you may notice any difference. This is dependant on how defecient you are and the anti-convulsant you are taking.
In extremely rare conditions folic acid may increase seizure frequency. Again this is very rare. If you start a nutrional program, you should keep a journal as to how you are feeling in general. Some people on folic acid have seen decreases in their seizure activity, while others have noticed they have more energy, sleep better and have less severe and frequent seizures. Each person, being unique, will have different starting values for folic acid. In my case I take 403mcg. per day.
Supplementation of folic acid should not be underestimated in it's effectivness.Folic acid has an important role in the production of red blood cells, which can be effected by certain anti-convulsants such as Depakote. At the very least it is promoting a healthier body and helps with side effects of anti-convulsant medication.
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