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Nuns’ Gift to Alzheimer’s Research: the Nun Study Reveals Clues about Alzheimer’s


© Brenda S. Parris

In 1991, David A. Snowdon, Ph.D., Professor at Sanders-Brown Center on Aging College of Medicine, University of Kentucky, Lexington began what has come to be known as the Nun Study. Participants in this study are 678 American members of the School Sisters of Notre Dame religious congregation. The nuns in the study are age 75 to 106.

These nuns make excellent subjects for this study as they don't smoke or drink, and they have common lifestyles and environment. With all of these factors in common, most of the problems that are confusing in other epidemiologic (concerned with the causes of disease) studies are eliminated or minimized.

As well as physical and mental examinations, the sisters autobiographical writings from years ago were examined. Among the findings were:

1. Those who had more linguistic ability in early life were less likely to have dementia later.

2. Those who showed positive emotions in early life had greater longevity.

3. Low linguistic ability in early life was associated both with dementia in later life and less longevity.

4. Those with low serum folate levels were more likely to have Alzheimer's disease of other dementia.

5. There was no significant relationship found between dental amalgams (silver fillings) and dementia.

6. Those with brain infarcts had poorer cognitive function and a higher prevalence of dementia.

7. Dementia was unrecognized by nursing staff in a number of cases.

8. Higher education in early life was associated with less cognitive decline in later life.

One nun, Sister Mary, had high cognitive test scores before her death at age 101, even though an atopsy revealed that she had the neurofibrillary tangles and plaques that are characteristics of Alzheimer's disease.

Dr. Snowdon has published the story of the Nun's Study and its findings in his book, Aging with Grace: What the Nun Study Teaches Us about Leading Longer, Healthier, and More Meaningful Lives (Bantam Doubleday Dell, 2001 - ISBN 0553801635)

The nuns of the School Sisters of Notre Dame have given so much of themselves in agreeing to participate in this study. Their gift tells us much of what we know about aging, Alzheimer's disease, and about possible preventions for dementia. The study continues, and perhaps from these nuns we will learn even more about preventing or possibly even curing Alzheimer's disease.

Related Web sites:

The Nun Study Web site - http://www.mc.uky.edu/nunnet/

The Book: Aging with Grace - http://www.mc.uky.edu/nunnet/AgingWithGr...

Sanders-Brown Center on Aging - http://www.mc.uky.edu/coa/

School Sisters of Notre Dame - http://www.ssnd.org/

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The copyright of the article Nuns’ Gift to Alzheimer’s Research: the Nun Study Reveals Clues about Alzheimer’s in Alzheimer's Disease is owned by . Permission to republish Nuns’ Gift to Alzheimer’s Research: the Nun Study Reveals Clues about Alzheimer’s in print or online must be granted by the author in writing.

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